1. Package leaflet: Information for the user. AVONEX 30 micrograms/ ml solution for Injection. (Interferon beta-1a). Pre-filled syringe. Read all of this leaflet. Package leaflet: Information for the user. AVONEX 30 micrograms/ml solution for injection in pre-filled pen. (Interferon beta-1a). Pre-filled pen. Read all of this. Formal hepatic drug metabolism studies with AVONEX PS/AVONEX PEN in This leaflet is part III of a three-part “Product Monograph”.

Author: Tazahn Nikozuru
Country: Czech Republic
Language: English (Spanish)
Genre: Medical
Published (Last): 26 October 2007
Pages: 273
PDF File Size: 8.73 Mb
ePub File Size: 13.99 Mb
ISBN: 154-1-59783-420-9
Downloads: 99324
Price: Free* [*Free Regsitration Required]
Uploader: Akinojora

Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate: Allergic reactions, including anaphylaxis have been reported with interferon beta-1a use. Many studies demonstrate that nevirapine is more hepatotoxic than efavirenz. Remove 1 Administration Dose Pack from refrigerator about 30 minutes prior to use to warm to room temperature. Also, do not inject into skin that is red, irritated, bruised, or infected. If you are commencing therapy on Powder for injection, you should speak to your doctor or MS nurse as to how to gradually increase your dose.

Do not use heat sources heater or hot water to warm it. Subcutaneous and intramuscular administration have been observed to have non-equivalent pharmacokinetic and pharmacodynamic parameters after administration to healthy volunteers. Related Drug Information Drug Summary. Do not re-use needles, syringes, pre-filled syringes, titration devices, or autoinjectors. The above list includes serious side effects that may require medical attention.

Pull off the sterile foil from the needle cover. With help from another person, may rotate between thighs and upper arms. Beta2-microglobulin, neopterin, and tryptophan, and inhibition of concanavalin-stimulated proliferation of peripheral blood mononuclear cells. Severe liver injury, including some cases of hepatic failure requiring liver transplantation, has been reported rarely in patients taking.

Digital Security

Prefilled syringes do not contain preservatives and are single-use only. Exercise caution when administering interferon beta-1a to patients with a preexisting seizure disorder. Premedication with acetaminophen or ibuprofen may lessen the severity of flu-like symptoms.

TOP Related Posts  BEURER PM45 PDF

Depression, suicidal ideation, suicide attempts, and development of new or worsening of preexisting psychiatric disorders, including psychosis, have been reported with interferon beta-1a see Adverse Reactions.

Patients with signs or symptoms of hepatitis, or with increased transaminases combined with rash or other systemic symptoms, must discontinue nevirapine and seek medical evaluation immediately. Although the exact mechanism of interferons in MS is unknown, it is thought that AVONEX works by decreasing the unwanted immune reaction against myelin. Nevirapine may cause liver damage in the context of hypersensitivity reactions or by direct toxic effects.

It does not contain all avone available information.

Patients with a history of depression 2 weeks prior to starting interferon beta-1a therapy may be at increased risk for developing depression during the first 2 months of therapy. Major Natalizumab should be used with caution with interferon beta because of the potential for increased risk of progressive multifocal leukoencephalopathy PML and other serious infections with combined use. Major The concomitant use of interferons and anti-retroviral non-nucleoside reverse transcriptase inhibitors NNRTIs should be done with caution as both can cause hepatic damage.

Interferon beta increases the levels inserg 2,5-oligo-adenylate Pzckage synthetase, an intracellular enzyme that is capable of degrading viral RNA. Use only for the person for whom it has been prescribed.

It does not take the place of talking to your specialist, doctor or pharmacist. Then grasp the cap and bend it at a 90 degree angle until it aovnex off. If the goal dose is 44 mcg, in weeks 1 to 2 administer 8.

If the goal dose is 22 mcg, in weeks 1 inserr 2 administer 4. Subcutaneous administration of interferon beta-1a should not be substituted for intramuscular administration. These side effects generally occur less often as therapy continues. Subcutaneous Injection Rebif prefilled syringe only: Keep all your doctor’s appointments so that your progress can be checked.

You and your doctor will decide what is best for you and your baby. The plastic needle cover will pop off after the injector shield has been fully extended. Interferon beta-1a Avonex 30 mcg is equivalent to 6 million International Units. Soreness, redness or bruising at the injection site.


PDR Search

Interferons and anti-retroviral nucleoside reverse transcriptase inhibitors NRTIs can both cause hepatotoxicity. Underlying chronic HCV infection enhances the risk of developing liver enzyme elevations in patients receiving nevirapine.

You may need urgent medical attention or hospitalisation. Hold Pen at 90 degree angle to the injection site. Seizures occurred during placebo-controlled trials in 4 patients receiving interferon beta-1a.

We’re strengthening digital security to protect you.

Use with caution in patients with hepatic disease. If you are not sure whether you should use this medicine, talk to your doctor or pharmacist. Hives or itchy skin. Treatment with interferon beta-1a should be immediately stopped if jaundice or other clinical signs of liver dysfunction appear; the potential for rapid progression to liver failure exists if avonwx drug is continued.

Avonex (interferon beta-1a) dose, indications, adverse effects, interactions from

The effect of interferon beta-1a on the medical management of patients with a inssrt disorder is unknown. Close the door over the syringe; a snap sound will occur when the door is closed correctly. Interferon beta belongs to the class of interferons, which are species-specific proteins produced in response to viruses as well as a variety of other natural and synthetic stimuli.

Ensure tamper-evident cap has not been removed or is loose. Concomitant use may increase the risk for hepatotoxicity. Monitoring of liver function tests is recommended at regular intervals 1, 3, and 6 months recommended for Rebif avohex initiation of therapy and then periodically thereafter in the absence of clinical symptoms.